2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N8821
    1-(4-Hydroxybenzoyl)glucose 25545-07-7 98%
    1-(4-Hydroxybenzoyl)glucose, a natural product found in Moricandia arvensis, Rhodiola chrysanthemifolia, acts as a bifunctional acyl and glucosyl donor.
    1-(4-Hydroxybenzoyl)glucose
  • HY-N8837
    Trifloroside 53823-10-2 98%
    Trifloroside is a secoiridoid glycoside with antioxidant effects. Trifloroside induces osteogenic effects through osteoblast differentiation, adhesion, migration, and mineral apposition. Trifloroside has the potential for osteoblast-mediated bone diseases research.
    Trifloroside
  • HY-N8917
    (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane 1180504-64-6 98%
    (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane is a homoisoflavonoid. (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane increases the level of alkaline phosphatase (ALP) activity. (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane promotes mesenchymal stem cells (MSCs) osteogenesis, but cannot enhance MSCs proliferation. (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane can be used for osteoporosis research.
    (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane
  • HY-N8945
    Meliasendanin D 1820034-05-6 98%
    Meliasendanin D (Compound 4) is a lignin. Meliasendanin D is isolated from the natural Melia toosendan fruit. Meliasendanin D has antioxidant activity.
    Meliasendanin D
  • HY-N8947
    Glyurallin A 199331-36-7 98%
    Glyurallin A (Compound 79) is isolated from the naturalGlycyrrhiza uralensis. Glyurallin A inhibitsα-Glucosidase(HY-P2802)(IC50=0.3 μM). Glyurallin A can be used in the study of anti-diabetes.
    Glyurallin A
  • HY-N8976
    7-(4-Hydroxy-3-methoxyphenyl)-1-phenylhept-4-en-3-one 79559-60-7
    7-(4-Hydroxy-3-methoxyphenyl)-1-phenylhept-4-en-3-one is a inhibitor of prostaglandin biosynthesis.
    7-(4-Hydroxy-3-methoxyphenyl)-1-phenylhept-4-en-3-one
  • HY-N8989
    (1,5E,11E)-Tridecatriene-7,9-diyne-3,4-diacetate 201012-14-8 98%
    (1,5E,11E)-Tridecatriene-7,9-diyne-3,4-diacetate, isolated from the ethanol extract of Atractylodes lancea rhizome, displays significant lipase inhibition with an IC50 value of 23.9 µg/mL. Antiobesity Effect.
    (1,5E,11E)-Tridecatriene-7,9-diyne-3,4-diacetate
  • HY-N9097
    Niazirin 122001-32-5 99.9%
    Niazirin is an orally active antioxidant. Niazirin can be isolated from Moringa oleifera Lam. Niazirin reduces the production levels of ROS and MDA, while increasing the levels of superoxide dismutase SOD and glutathione peroxidase GPx. Niazirin also abolishes high glucose-induced PKCζ activation and inhibits Nox4 protein expression. Niazirin exhibits excellent free radical scavenging activity. Niazirin significantly inhibits high glucose-induced proliferation of vascular smooth muscle cells. Niazirin can be used in the research of diabetic atherosclerosis.
    Niazirin
  • HY-N9226
    Glucocheirolin 15592-36-6 98%
    Glucocheirolin, a natural compound that can be isolated from Erysimum corinthium Boiss, possesses antinutritional and toxic effects in rats.
    Glucocheirolin
  • HY-N9275
    Isopicropodophyllin 60660-50-6 98%
    Isopicropodophyllin is a natural compound that can be used for metabolic or chronic inflammatory disorder research.
    Isopicropodophyllin
  • HY-N9295
    3,4-Seco-4(23),20(29)-lupadiene-3,28-dioic acid 36138-41-7 98%
    3, 4-seco-4 (23),20(29) -Lupadiene-3,28-dioic acid (Compound 5) is a triterpenoid compound. 3, 4-seco-4 (23),20(29) -Lupadiene-3,28-dioic acid has a strong inhibitory effect on the production of superoxide anions, and the inhibitory rate is 86.9±2.8% at 1 μM .
    3,4-Seco-4(23),20(29)-lupadiene-3,28-dioic acid
  • HY-N9314
    Camellianin B 109232-76-0 98%
    Camellianin B, a flavonoid compound, is a Camellianin A metabolite. Camellianin B has antioxidant and angiotensin converting enzyme (ACE) inhibitory activities.
    Camellianin B
  • HY-N9348
    Glucoraphenin 28463-24-3 98%
    Glucoraphenin, the predominant and orally active glucosinolate in radish sprouts, is hydrolyzed by myrosinase to sulforaphene that is implicated to exert anticancerogenic effects. Glucoraphenin induces xenobiotic metabolizing enzymes (XMEs).
    Glucoraphenin
  • HY-N9363
    Corymbiferin 5042-09-1 98%
    Corymbiferin is one of active constituents, responsible for anti-diabetic properties. Corymbiferin improves antioxidant capacity and carbohydrate metabolism in diabetic rats, along with the improvement of histopathology of livers and pancreatic β cells.
    Corymbiferin
  • HY-N9387
    Macarangioside D 819870-23-0 98%
    Macarangioside D, a megastigmane glucoside, possesses radical-scavenging activity.
    Macarangioside D
  • HY-N9434
    5,7,2',6'-Tetrahydroxyflavone 82475-00-1
    5,7,2',6'-Tetrahydroxyflavone is a natural flavonoid that inhibits hepatic testosterone 6β-hydroxylation (CYP3A4) activity with an IC50 of 7.8 μM.
    5,7,2',6'-Tetrahydroxyflavone
  • HY-N9515
    Diallyl tetrasulfide 2444-49-7 98%
    Diallyl tetrasulfide is an orally active diallyl tetrasulfide. Diallyl tetrasulfide ameliorates cadmium-induced changes in acetylcholinesterase and adenosine triphosphatase activities as well as oxidative stress injury in the brain of rats. Diallyl tetrasulfide inhibits lipid peroxidation in rat liver microsomes. Diallyl tetrasulfide ameliorates cadmium-induced oxidative liver injury in rats. Diallyl tetrasulfide protects cells against cadmium-induced loss of cell viability, reduces apoptosis rate and ROS production. Diallyl tetrasulfide is applicable to research related to cadmium-induced neurotoxicity and cadmium-induced oxidative liver injury.
    Diallyl tetrasulfide
  • HY-N9524
    Ilexoside XLVIII 129095-76-7 98%
    Ilexoside XLVIII is an acyl CoA cholesteryl acyl transferase (ACAT) inhibitor. Ilexoside XLVIII is a triterpene saponin isolated from an aqueous extract of the leaves of Ilex kudincha.
    Ilexoside XLVIII
  • HY-N9530
    1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone 120693-53-0 98%
    1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone, a quinolone alkaloid, is a diacylglycerol acyltransferase inhibitor and angiotensin II receptor blocker, with IC50s of 20.1 μM and 34.1 μM, respectively. 1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone shows potent anti-Helicobacter pylori activity with the MIC of 10 μg/mL.
    1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone
  • HY-N9535
    tert-OMe-byakangelicin 79638-04-3 98%
    tert-OMe-byakangelicin is a coumarin that can enhances the adrenaline-induced lipolytic effect and inhibits insulin-stimulated triglyceride synthesis from glucose in fat cells.
    tert-OMe-byakangelicin
Cat. No. Product Name / Synonyms Application Reactivity